Inside the Science of Pediatric Lung Disease

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Speeding Up Science With Patient-Derived Xenografts

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Featured Researcher – Beth Kozel, MD, PhD
 Featured Researcher – Beth Kozel, MD, PhD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Genomic medicine is a revolutionary chapter within science, evolving at an exponential rate. At Nationwide Children’s, the Steve and Cindy Rasmussen Institute of Genomic Medicine brings the rapidly advancing science to the clinic to improve diagnosis, therapies and outcomes for children with gene-based conditions.…

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Dr. Kallash standing in an office hallway, wearing a white coat and red tie.
Renal Artery Stenosis Perspectives: A Conversation With Nephrologist Mahmoud Kallash, MD
 Renal Artery Stenosis Perspectives: A Conversation With Nephrologist Mahmoud Kallash, MD 1024 683 Gina Vitale, PTA
By: Gina Vitale, PTA

Mahmoud Kallash, MD, is a glomerular disease expert, the director of the Comprehensive Hypertension Program at Nationwide Children’s Hospital, a principal investigator and an associate professor in pediatrics at The Ohio State University College of Medicine. Here, Dr. Kallash discusses current treatment obstacles, ongoing…

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physicians in white coats looking at a tablet
Rumination Syndrome May Be Underrecognized in Children With Eosinophilic Esophagitis
 Rumination Syndrome May Be Underrecognized in Children With Eosinophilic Esophagitis 1024 683 Madison Storm
By: Madison Storm

New research highlights the importance of considering co-diagnoses in children with persistent regurgitation. Regurgitation is a common symptom in both eosinophilic esophagitis (EoE) and rumination syndrome (RS), but new research suggests the overlap between the two conditions may be greater than previously recognized. The…

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Study Reveals Challenges in Cardiac Transplantation Referrals for High-Risk Infants
 Study Reveals Challenges in Cardiac Transplantation Referrals for High-Risk Infants 1024 670 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Findings from a recent retrospective study demonstrate challenges and inequities in cardiac transplantation referrals for infants with single ventricle congenital heart disease, suggesting the need to improve access to transplantation and the timing and rate of transplantation referral.   A retrospective study led by…

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Dr. DaJusta, urologist, standing in a hospital hallway smiling.
Robotic Pyeloplasty Is a Viable Option for Infants Younger Than 6 Months
 Robotic Pyeloplasty Is a Viable Option for Infants Younger Than 6 Months 1024 677 Lauren Dembeck
By: Lauren Dembeck

A Nationwide Children’s study found comparable outcomes with robotic and open pyeloplasty in infants younger than 6 months, suggesting patient size alone should not preclude a robotic approach.   Robotic pyeloplasty appears to be a viable alternative to open surgery even in infants younger…

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Molly Fuchs, MD, chief of Urology at Nationwide Children's, wearing scrubs and a white coat standing in a hospital hallway.
Early Vesicostomy May Help Predict Long-Term Urinary Outcomes in Girls With Cloacal Malformation
 Early Vesicostomy May Help Predict Long-Term Urinary Outcomes in Girls With Cloacal Malformation 1024 611 Lauren Dembeck
By: Lauren Dembeck

The need for vesicostomy in infancy may help identify girls with cloacal malformation who are at greater risk for impaired bladder function, chronic kidney disease, and future reconstructive surgery.   Girls born with cloacal malformation who require a vesicostomy in infancy may be less…

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Baby with tracheostomy tube happily engaging with medical team who are holding a toy and wearing masks and gowns.
Supporting Brain Development While the Lungs Heal
 Supporting Brain Development While the Lungs Heal 1024 683 Pam Georgiana
By: Pam Georgiana

A new review presents a practical framework for incorporating neurodevelopmental care into the management of infants with severe bronchopulmonary dysplasia. For infants with severe bronchopulmonary dysplasia (BPD), months in the Newborn Intensive Care Unit (NICU) can coincide with a critical period of brain development.…

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A man with Duchenne muscular dystrophy sits in a wheelchair between two family members
Mutation-Specific Therapy Brings New Hope for Patient With Duchenne Muscular Dystrophy
 Mutation-Specific Therapy Brings New Hope for Patient With Duchenne Muscular Dystrophy 1024 484 Abbie Miller
By: Abbie Miller

Justin Nicholoff is the first patient at Nationwide Children’s to receive del-zota through a managed access program. Since research into exon skipping therapies for Duchenne muscular dystrophy (DMD) took off about 15 years ago, Justin Nicholoff has waited for a therapy designed for his…

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MRI or magnetic resonance image of head and brain scan. Close up view, toned image
Brain Imaging Study Reveals Unexpected Glymphatic Pattern in Adolescent Psychosis
 Brain Imaging Study Reveals Unexpected Glymphatic Pattern in Adolescent Psychosis 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Higher glymphatic imaging markers in adolescents contrast with patterns reported in adult studies, highlighting the importance of developmental stage for biomarker interpretation. A new neuroimaging study from investigators at Nationwide Children’s Hospital suggests that adolescents with first-episode of psychosis (FEP) may have increased activity…

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Woman in scrubs with a stethoscope talking with teen.
Insurance-Driven Switches to Adalimumab Biosimilars Maintain Disease Control in Pediatric Inflammatory Bowel Disease
 Insurance-Driven Switches to Adalimumab Biosimilars Maintain Disease Control in Pediatric Inflammatory Bowel Disease 1024 683 Pam Georgiana
By: Pam Georgiana

New pediatric data may help clinicians reassure patients and families about nonmedical treatment switches Since biosimilar versions of adalimumab became available in the United States in 2023, more insurers have required patients receiving the originator medication to switch to a biosimilar. Researchers have deemed…

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Treating Cystic Fibrosis Before Birth May Prevent Some of Its Earliest Complications
 Treating Cystic Fibrosis Before Birth May Prevent Some of Its Earliest Complications 1024 575 Abbie Miller
By: Abbie Miller

At Nationwide Children’s, fetal medicine and pulmonary specialists are collaborating to offer an emerging prenatal treatment approach. For children with cystic fibrosis, disease-related injury can begin before birth. Now, clinicians at Nationwide Children’s are using a cystic fibrosis transmembrane conductance regulator modulator — commonly…

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EEG brain waves on black background
Open-Source Tools to Profile Space-Time Slow Oscillations in Dormant Sleep Data
 Open-Source Tools to Profile Space-Time Slow Oscillations in Dormant Sleep Data 1024 640 Jessica Nye, PhD
By: Jessica Nye, PhD

The Brain Rhythms Lab at Nationwide Children’s Hospital releases open-source tools for extracting space-time profiles in sleep data. “The kind of thing we’d like to understand is what in the sleep neurophysiology of children with typical or atypical development can inform us on the…

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A hand adjusts the weight measurement on a doctor's scale in a healthcare setting.
A New Era in Pediatric Obesity Treatment
 A New Era in Pediatric Obesity Treatment 1024 683 Joan Han, MD
By: Joan Han, MD

For decades, pediatric obesity treatment options were limited. Clinicians relied primarily on lifestyle interventions, with few effective medications available for children and adolescents. Today, however, advances in obesity medicine are transforming care and creating new opportunities to improve long-term health outcomes for young patients.…

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Integrated Crisis Care Continuum Expands Access for Youth and Families
 Integrated Crisis Care Continuum Expands Access for Youth and Families 1024 683 Lauren Dembeck
By: Lauren Dembeck

Nationwide Children’s comprehensive crisis care continuum connects youth and families with timely, individualized mental health support across hospital, outpatient and community settings.   As pediatric mental health needs continue to rise, Nationwide Children’s has developed an integrated crisis care continuum designed to connect children…

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Newborn baby in an NICU bed with a nasogastric tube.
Could Missed Feeding Milestones Be Driving NICU Complications?
 Could Missed Feeding Milestones Be Driving NICU Complications? 1024 492 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

New research suggests delayed feeding progression may contribute to growth faltering, prolonged hospitalization and other complications in very preterm infants. For years, clinicians have largely assumed that preterm infants reach feeding milestones later because they are sicker. New research from Nationwide Children’s suggests the…

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Science Inspired Abstract Art - An abstract composition inspired by scientific elements like beakers, test tubes, or molecular structures, chemistry, biology, physics
A New Tool Opens New Door to Personalized Genetic Risk Assessment
 A New Tool Opens New Door to Personalized Genetic Risk Assessment 1024 574 Madison Storm
By: Madison Storm

PGS Browser integrates thousands of polygenic scores and provides new tools and resources for their interpretation, helping to bridge the gap between genomic research and clinical application. A new study led by investigators from the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s…

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Cute baby lies in a white round bed. Light nursery for young children. Toys for infant cot. Smiling child playing with mobile of felt and chewing his feet in sunny bedroom.
Novel Ligamentum Teres Reconstruction Technique May Improve Hip Development in Developmental Hip Dysplasia
 Novel Ligamentum Teres Reconstruction Technique May Improve Hip Development in Developmental Hip Dysplasia 1024 684 Pam Georgiana
By: Pam Georgiana

Children treated with a novel suture button technique experienced improved acetabular remodeling following open hip reduction. Achieving a stable reduction, in which the femoral head remains securely positioned within the hip socket, is the primary goal of treatment for developmental dysplasia of the hip…

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Baby in a NICU bed with nasal canula. Swaddled in white blanket with health care worker's hand gently resting on the baby.
Planning Starts During Pregnancy for the Fastest Genome Sequencing in the NICU
 Planning Starts During Pregnancy for the Fastest Genome Sequencing in the NICU 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Genome sequencing (GS) has become standard for babies with congenital anomalies in the neonatal intensive care unit (NICU) at Nationwide Children’s.   To ensure that clinicians have access to genomic results as soon as possible, GS coordination is moving to the gestational period for…

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test tube of blood held in gloved hands
International Framework Establishes Path Toward Risk-Adapted Osteosarcoma Treatment
 International Framework Establishes Path Toward Risk-Adapted Osteosarcoma Treatment 1024 575 Lauren Dembeck
By: Lauren Dembeck

A new international framework prioritizes molecular classifiers that could enable risk-adapted, biologically informed treatment for children, adolescents, and young adults with osteosarcoma.   Despite substantial advances in understanding osteosarcoma biology, treatment has remained largely unchanged for more than four decades. An international working group…

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MRA Brain or Magnetic resonance angiography (MRI) of Vessel in the brain sagittal view for evaluate them stenosis
Study Supports Use of Flow-Diverting Stent for Complex Brain Aneurysms in Children
 Study Supports Use of Flow-Diverting Stent for Complex Brain Aneurysms in Children 1024 531 Lauren Dembeck
By: Lauren Dembeck

New research suggests that a minimally invasive flow-diversion device approved for adults may offer a safe and effective treatment option for children with complex brain aneurysms. Pediatric intracranial aneurysms are rare, but when they occur, they can be among the most challenging cerebrovascular conditions…

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